Pregnancy Tests: Diagnostic pregnancy exams based upon immunological reactions between HCG and anti-HCG may well bring about Untrue-detrimental or Fake-favourable interpretations.
Codeine has fantastic antitussive exercise, Though fewer than that of morphine at equal doses. It's used in choice to morphine, due to the fact Unwanted side effects are infrequent at the standard antitussive dose of codeine.
are pregnant or plan to be pregnant. Promethazine Hydrochloride and Codeine Phosphate Oral Resolution can harm your unborn child. See “What on earth is The main facts I really should know about Promethazine Hydrochloride and Codeine Phosphate Oral Resolution?” are breastfeeding or intend to breastfeed. Codeine passes into your breast milk and could potentially cause significant side effects within your child which include increased sleepiness, breathing problems (respiratory depression), and death. It's not acknowledged if promethazine can pass into your breast milk.
Antihistamines are contraindicated for use during the therapy of lower respiratory tract indications, which include bronchial asthma.
When offered concomitantly with Promethazine HCl Oral Answer, the dose of barbiturates must be minimized by not less than one-50 %, as well as dose of narcotics need to be lessened by just one-quarter to 1-50 %. Dosage have to be individualized. Excessive quantities of Promethazine HCl relative to a narcotic could result in restlessness and motor hyperactivity while in the individual with pain; these indicators ordinarily disappear with suitable control of the suffering.
Because recurrences of NMS are already reported with phenothiazines, the reintroduction of promethazine HCl should be meticulously thought of.
Sedation This product or service relieves apprehension and induces a silent rest from which the affected person might be very easily aroused.
Promethazine HCl and Codeine Phosphate Oral Solution is indicated with the short term reduction of coughs and higher respiratory read more indicators linked to allergy or even the typical cold in individuals 18 years of age and more mature.
Promethazine HCl Oral Alternative is contraindicated in comatose states, and in people today regarded to generally be hypersensitive or to acquire experienced an idiosyncratic reaction to Promethazine or to other phenothiazines.
Asthma Along with other Respiratory Ailments: Narcotic analgesics or cough suppressants, together with codeine, should not be Utilized in asthmatic clients (see CONTRAINDICATIONS). Nor should they be used in acute febrile illness linked to effective cough or in Serious respiratory illness where interference with power to apparent the tracheobronchial tree of secretions would've a deleterious impact on the affected individual’s respiratory operate.
Promethazine is definitely an antihistamine which can be taken by mouth as an oral Answer or pill, rectally like a suppository, or by injection. It can be employed for:
The opioid antagonists, naloxone and nalmefene, are particular antidotes for respiratory melancholy ensuing from opioid overdose. For clinically significant respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered from the absence of clinically sizeable respiratory depression. As the length of opioid reversal is predicted being less than the duration of motion of codeine in Promethazine HCl and Codeine Phosphate Oral Alternative, meticulously observe the patient till spontaneous respiration is reliably reestablished.
Sedation This products relieves apprehension and induces a tranquil rest from which the affected individual is usually quickly aroused.
Codeine Carcinogenicity studies have been executed with codeine. Two-year scientific studies in F344/N rats and B6C3F1 mice ended up conducted to assess the carcinogenic likely of codeine. No evidence of tumorigenicity was observed in male and woman rats at codeine dietary doses up to 70 and 80 mg/kg/day (around reminiscent of fifteen and twenty times, the MRHD on a mg/m2 basis, respectively).